It’s Friday, folks. Time to stop.

One of my ideas for making the transition to retirement less sharp, is to have an end of week routine. Fridays have been, and remain, the end of the week for me. During my working life, my partner and I usually stayed home on Friday evenings, hanging out, sharing what we had learned, heard, and seen over the week. It was a time to stop striving and just be. A time to put away the phone, go for a walk together. Ask questions. Breathe in. Breathe out. Let worry go.

The routine isn’t exactly the same now that we are living up north. However, it is in that spirit, that I offer this end of week note with a few of the things things I found interesting this week:

Some thoughts on the future of work for those nearing the end of their careers. Lots of exclamation points. I haven’t seen these kind of opportunities, but if you are in the right situation, you might be able to navigate there from where you are today.

A March 2016 Commonwealth Club interview with Douglas Rushkoff, author of Throwing Rocks at the Google Bus. He is energetic and passionate about the intersection of the human and the marketplace, including topics like the purpose of jobs, the game-ification of the marketplace, and the evolving dynamics between land, capital, and labor. His view is congruent with Yuval Noah Harari’s, another favorite thinker of mine. I highly recommend you spend the hour it takes to listen to this.

In the NYTimes, Jane Brody considers “Who really needs to be gluten free?” and concludes that more of us need to be gluten free than are presently. Of course, I’d go further and say lectin free.

The/Thirty offers a short summery of Dr Steven Gundry’s Plant Paradox here. As I mentioned elsewhere, I have been eating lectin-free for about seven weeks now. I have lost about 12 pounds. More significantly, I have zero cravings, and even when confronted with my formerly favorite foods, I just don’t feel interested enough to eat them again. Really makes me wonder whether my brain or my gut was making food decisions in the past.

FiveThirtyEight offers a five part overview of the state of gut health science here.

How to stimulate your vagus nerve. That is the ‘highway’ between your gut and your brain, and might be the way that a disease that begins in the gut could travel to the brain. Turns out humming is good for you!

For those of you who have had the pleasure of even one meal in or around Lyon, France here’s a summary by Food52 of how the vegetarian/vegan influencing is being manifest there. Yum.

I have been watching a lot of interviews with Dr Sachin Patel recently. I am impressed with his philosophy and the work he is doing at the Living Proof Institute. The Institute has three guiding principles for working with patients: they co-create health (as opposed to treating disease), they agree that most diseases involve what goes into your mouth (and what comes out of your mouth, or what you hold back), and they believe the doctor doesn’t determine the outcome – the patient does. They offer a 30-day program that offers a tip a day to “become proof” that you can architect your own health. Sign up for the 30 days here.

Finally, Diana Krall has a new album. Take a listen. Hum along. And enjoy your weekend!

The Plant Paradox by Steven Gundry MD

I found this book on the goop page on Instagram (I know, I know). I’m not sure what grabbed my attention, but I read it and the science seemed sound. We have been following the diet for just over 3 weeks now. We have both lost weight, and are feeling good about what we feel going on in our gut. I am hopeful that eliminating lectins from my diet will boost my immune system, breed healthier mitochondria in the future, and stop causing stress on my vagus nerve. It is thought that if Parkinson’s Disease begins in the gut, it is this vagus nerve that allows it to travel to the brain. Obviously I need to learn more about this mechanism, but I like what I am eating and I like how I feel.

“If you are experiencing memory loss, Parkinson’s, or neuropathy, exciting research suggests that the exhausted Mighty Mice (mitochondria) in your nerve cells can come back to life if they are fed ketones instead of sugar.” Gundry, Steven R., M.D.

It is easy to look up research, references, and resources in this book, using the footnotes. In this case, here is what researchers Maalouf, Rho, and Mattson conclude from their study “The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies.”

“Calorie restriction and the ketogenic diet share two characteristics: reduced carbohydrate intake and a compensatory rise in ketone bodies. The neuroprotective effects of reduced carbohydrate per se are being investigated by several research groups (Mattson et al. 2003; Ingram et al. 2006). We have evaluated the possibility that ketone bodies might mediate the neuroprotective effects of calorie restriction and of the ketogenic diet. An expanding body of evidence indicates that ketone bodies are indeed neuroprotective and that the underlying mechanisms are similar to those associated with calorie restriction – specifically at the mitochondrial level.

However, several important questions remain unanswered. The effects of ketone bodies on gene expression have not been investigated, although inhibition of glycolysis with 2-deoxyglucose (which blocks phosphofructose isomerase) has been reported to inhibit BDNF expression and kindling progression in rats (Garriga-Canut et al, 2006). Moreover, the neuroprotective of ketone bodies in vivo have not been thoroughly examined. For instance, it is imperative to demonstrate that the neuroprotective effects of ketone bodies are associated with a preservation of clinically relevant functions such as cognition. Finally, it is crucial to determine if the anti-apoptotic properties of ketone bodies might potentially increase the risk of carcinogenesis. Intriguingly, both the calorie restriction and the ketogenic diet have been associated with anti-neoplastic properties and similarly, preliminary data suggest that the ketone bodies β-hydroxybutyrate and acetoacetate have anti-neoplastic effects on human glioblastoma cell lines (Patel et al. 2004; Jolly 2006 Zhou et al. 2007). Further research will hopefully further clarify the mechanisms underlying the neuroprotective properties of calorie restriction and ketone bodies and explain the counter-intuitive effects on carcinogenesis.”

Parkinson’s Research Project

I’m really excited to learn about this new research project from Dr Terry Wahls. Basically this team will survey all participants every six months for five years, and try to identify what impact alternative treatments might be having on the course of their Parkinson’s Disease. I am working on both my mitochondrial health through diet and lifestyle, and my brain’s neuroplasticity through learning and movement. It is my hope that I can model how to slow or halt this disease. I’d urge anyone with a Parkinson’s diagnosis to participate; it took me about 30 minutes to answer the first survey.